Protective effects of polyphenols of vitis amurensis Rupr on rat oxidative damage caused by chronic alcohol intakes
- VernacularTitle:山葡萄多酚对酒精慢性中毒大鼠氧化损伤的保护作用
- Author:
Weiqun DAI
;
Haijing NI
;
Shuping JIAO
- Publication Type:Journal Article
- Keywords:
polyphenols of vitis amurensis Rupr;
chronic alcohol intakes;
oxidative damage
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of the polyphenols of vitis amurensis Rupr(PVAR) on oxidative damage in rats caused by chronic alcohol intakes.Methods Forty male Wistar rats were divided into 4 groups according rats' weights: normal control group,alcohol injury group(the rats were treated with 10 mL?kg-1 33% alcohol via i.g);PVAR group(after ingesting 200 and 400 mg?kg-1 PVAR,the male rats were treated with 10 mL?kg-1 33% alcohol via i.g).After 8 weeks,the concentrations of malondialdehyde(MDA),reactive oxygen species(ROS),glutathione(GSH) and the activities of SOD and heme oxygenase-1(HO-1) in rat liver tissues were measured.The activities of serum glutamic-pyruvic transaminase(GPT) and glutamic oxaloacetic transaminase(GOT) in rats were measured.Results Compared with alcohol injury group,the concentrations of MDA,ROS,GPT and GOT were decreased significantly(P
