Preliminary approach on application of recombinant human 2-glycoprotein-1 domain Ⅰ dimer as B lymphocyte tolerogen
- VernacularTitle:重组人?2糖蛋白1第一结构域二聚体作为抗磷脂抗体综合征B细胞耐受原的初步探讨
- Author:
Jia FU
;
Yan TAN
;
Yanqiu FANG
;
Bin XIONG
;
Li XU
- Publication Type:Journal Article
- Keywords:
recombinant human 2-glycoprotein-1;
domain Ⅰ dimer;
anti-phospholipid antibody syndrome;
B lymphocyte tolerogen
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the suppression to 2-glycoprotein-1-specific B cell response by human recombinant 2-glycoprotein-1 domain Ⅰ dimer(rh?2-GP1-DⅠ2) in rh?2-GP1 immunized mice.Methods The effects of treatment using rh?2-GP1-DⅠ2 on titer and ratio of anti-?2-GP1 were analyzed by solid phase ELISA.The number of splenic ?2-GP1-specific antibody-forming cells(AFC) was counted by ELISPOT.Results The levels of anti-?2-GP1 from rh?2-GP1 immunized mice treated with rh?2-GP1-DⅠ2 were significantly decreased compared with those in negative controls(P
