The effects of Nutrison on rat gut barrier after 5-FU chemotherapy

VernacularTitle:能全素对5-FU化疗后大鼠肠屏障功能的影响
Author: Fuming LEI ; Xuening DUAN
Publication Type:Journal Article
Keywords: 5-FU; enteral nutrition gut barrier; intestinal permeability
From: International Journal of Surgery 2009;36(5):310-313,封3
CountryChina
Language:Chinese
Abstract: Objective To investigate and assess the effects of nutrison on rat gut barrier after 5-FU chemo-therapy. Methods Thirty male Sprague-Dawley rats were randomly assigned to three groups: EN group: nutrison intestinal nutrition; STD group: nutrison intestinal nutrition + chemotherapy; CHOW group: chow+ chemotherapy. The changies such as weight, lactulose / mannitol of urine samples before and after chem-otherapy were observed. At the 8th day, colon as well as jejunum tissue were also sampled for pathological examination to measure the height of jejunum villi, the thickness of colon and jejunum. Results Compared to EN group, the body weight the height of jejunum mucosa and the thickness of colon / jejunum loss of STD group was significantly decreased, as well as the L/M inceased. The data showed that CHOW group was bet-ter than EN group. Conclusions Intraperitoneal injection of 5-FU increased the intestinal permeability of rats and damaged the function of intestinal barrier. The intestinal mucosal protection effect of nutrison EN in post-chemotherapy rats was weaker than the effect of a free-eating group.