Antioxidative effect of sodium ozagrel on myocardial ischemia in rats
- VernacularTitle:奥扎格雷钠对大鼠心肌缺血的抗氧化作用
- Author:
Limei BU
;
Suisheng WU
;
Hongying HE
- Publication Type:Journal Article
- Keywords:
ozagrel;
myocardial ischemia;
malonaldehyde;
superoxide dismutase
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To disccuss the antioxidative effects of sodium ozagrel(OZG) in myocardial ischemia in rats and illuminate its effect of decreasing oxidative damage.Methods Forty healthy Wistar rats were randomly devided into five groups:control,model,pretreatment,treatment and therapeutic alliance groups.OZG was used for 2 weeks in pretreatment group,then isoprenaline hydrochloride (ISO) was applied to make myocardial ischemia model.5 min after the establishment of model,OZG and OZG combined with glyceryl trinitrate(GT) were used in treatment group and therapeutic alliance group,respectively,ECG was recorded at the same time.1 h later,the activities of serum myocardial creatases(AST,LDH,CK),malonaldehyde(MDA) level and superoxide dismutase(SOD) activity were detected.Results ECG:When the model was successfully set up,ST segment in every group all raised≥0.1 mV,the minimum value of raise was in pretreatment group.When the model was succeeded 5 min later,ST segment in model group slightly decreased but still ≥0.1 mV and it was significant in pretreatment group.In treatment and therapeutic alliance groups,compared with model succeeding'ST segment,ST segment decreased significantly at 5 min later(P
