Tumor suppressing and immune regulation effects of cadmium chloride in S180 sarcoma mouse models
- VernacularTitle:氯化镉对小鼠S180肉瘤的抑制作用及其对免疫功能的影响
- Author:
Yehui TAN
;
Yan LI
;
Wei LI
;
Jing SHEN
;
Xiuli YUAN
;
Guanjun WANG
- Publication Type:Journal Article
- Keywords:
cadmium chloride;
S180 sarcoma;
immune function
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the tumor suppressing effect of cadmium chloride on S180 sarcoma,and to explore its favoriable dosage.Methods The mouse models bearing S180 sarcoma were treated with cadmium chloride with dosages of 0.25,1.00 and 4.00 mg?kg-1,the anti-tumor effect was evaluated by calculating of tumor weight;spleen and thymus indexes,carbon phage assay,lymphocyte transformed assay and hematolysis assay were used to measure the effect of cadmium chloride on immune function.Results Cadmium chloride with varied dosage of 0.25,1.00 and 4.00 mg?kg-1 inhibited the growth of S180 sarcoma,the tumor weights in cadmium chloride groups were significantly lower than that in control(P
