Preparation of arbidol hydrochloride multi-layers controlled-released and evaluation of its release rate in vivo and in vitro
- VernacularTitle:盐酸阿比朵尔多层缓释片的制备及体内外释放度的评价
- Author:
Shuqin ZHANG
;
Zhiyi LIU
;
Fuming ZHANG
;
Fei SUN
- Publication Type:Journal Article
- Keywords:
arbidol hydrochloride;
multi-layers controlled-released preparation;
release rate
- From:
Journal of Jilin University(Medicine Edition)
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the development of Arbidol hydrochloride(Ahyd) multi-layers controlled-released preparation and evaluate its release rate in order to provide the basis for Ahyd pharmacodynamics reseach.Methods Ahyd multi-layers was used as experiment group and Ahyd single-layer as control,high performance liquid chromatography(HPLC) was used to examine releasing level of two groups for calculating parameters of drug metabolism and bioavailability.Results Compared with Ahyd single-layer,the multi-layers controlled-released preparation had several significant advantages as below:Cmax fell remarkably(P
