Expression of NF-κB and dendritic cells in renal tissue of lupus nephritis
10.3760/cma.j.issn.1008-6706.2009.04.017
- VernacularTitle:狼疮肾炎患者肾组织核因子-κB和外周血树突状细胞的表达
- Author:
Ying LIU
;
Yongjun SHI
;
Jiahao ZHONG
;
Weiqiang ZHONG
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
NF-Kappa B;
Dendritic cells;
T lymphocytes;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(4):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore expression of nuclear factor kappa B (NF-κB) and change of peripheral blood dendritic cells(DCs) surface. Methods The expression of NF-κB and DCs in kidney of 40 LN cases were measured,by ALP-anti-ALP mice immune complex law(APAAP) and density gradient separation centrifugal meth-ods. Results kidney tissue of LN patients, NF-κB in the glomeruli and tubules showed a high level of expression ; CD80+ ,CD86+, HLA-DR+ expression decreasedtacrolimus group than the control group Division before and after the shape of the DCs had no effect on tacrolimus after the DCs could inhibit the proliferation of T cells and T cells to Th2 cell transformation. Conclusinn In vitro Tacrolimus inhibits the DCs mature in LN patients, NF-κB in LN kidney LN local expression and the occurrence and development of related.
