Recent progress in the research of the impact of glucagon-like peptide-1 on islet β-cells
- VernacularTitle:胰升糖素样肽1对胰岛β细胞作用的研究进展
- Author:
Tianhong LUO
;
Yiman ZHENG
- Publication Type:Journal Article
- Keywords:
Glucagon-like poptide-1;
Glucagon-like poptide-1 receptor;
Islet β-cells
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(6):附录6b-4
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon-like poptide-1 (GLP-1) is an incretin secreted by the enteroendocrine L cells of the gut. Upon the activation of GLP-1 receptor, adenylyl cyclase is activated and cAMP is generated, leading to the activation of protein kinase A and Epac signal pathway. GLP-1 could also activate calcium/calmodulin pathway as well as mitogen-activated protein kinases and phosphatidyl inositol-3 kinase pathway. GLP-1 not only stimulates the phase 1 and phase 2 insulin secretion, but also increases insulin synthesis. GLP-1 also stimulates proliferation and differentiation of islet β-cells, and protects β-cell from apoptosis and modulates endoplasmic reticulum stress response leading to promotion of β-cell adaptation and survival.
