Small ubiquitin-like modifier and cancer
- VernacularTitle:小泛素样修饰物修饰与肿瘤相关研究进展
- Author:
Xiaojun DING
;
Jian SUN
- Publication Type:Journal Article
- Keywords:
Neoplasm;
Small ubiquitin-like modifier;
Sentrin specific protease
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Small ubiquitin-like modifiers(SUMO) are ubiquitin-related proteins that can be covalently conjugated to cellular target proteins.Frequently,this modification has a key role in regulating the activities of those targets and,hence,their cellular functions.Researches show that some oncoproteins,tumor suppressors,DNA repair proteins and cyclins are target proteins of SUMO modification and the altered expression of some enzymes related to SUMO conjugation occurs in some neoplasm.It is indicated that sumoylation is important in tumor origination,development and metastasis.
