Dexamethasone improves expression of basic fibroblast growth factor in neurons of spinal cord following sciatic nerve injury in rats
- VernacularTitle:地塞米松对大鼠坐骨神经损伤后脊髓神经元碱性成纤维细胞生长因子的影响
- Author:
Yan ZHOU
;
Xiangmin YU
;
Ling LI
;
Xiaoliang PAN
- Publication Type:Journal Article
- Keywords:
Sciatic nerve injury;
Rat;
Basic fibroblast growth factor;
Dexamethasone;
Motor neuron
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The regeneration and repair of peripheral nerves are focuses of neurological studies.The(bFGF) may play an important role in the development of the neural system.Dexamethasone is usually employed in the management of neural injuries.The aim of this study is to establish a rat model,and investigate the effect of Dexamethasone on the expression of bFGF in the neurons of the spinal cord following sciatic nerve injury.Methods: Fifty-six male Wistar rats were randomly divided into 4 groups: a nerve injury group,with sciatic nerve injury induced by clamping the nerve in the right;a dexamethasone group,immediately injected with dexamethasone [0.5 mg/(kg/d)] in the injury side;a saline group,given saline only;and a control group,rats without sciatic nerve injury.Changes of bFGF in the motor neurons of the L4-L6 spinal cords were observed by immunohistochemistry.Results: Dexamethasone obviously upregulated the expression of bFGF in the motor neurons of the spinal cord.Conclusion: Dexamethasone can improve the expression of bFGF in the motor neurons of the spinal cord after sciatic nerve injury,and contribute to the recovery of the function of the injured neurons.
