Apoptotic induction of Aspisol on melanoma A375 cells
10.3760/cma.j.issn.1008-6706.2009.03.022
- VernacularTitle:赖氨匹林对人恶性黑色素瘤A375细胞凋亡的诱导作用
- Author:
Xiaojun LI
;
Yuelin ZHANG
;
Yun YE
;
Meiling YU
;
Ziguang LI
;
Xiaoguang ZHU
- Publication Type:Journal Article
- Keywords:
Aspisol;
Melanoma;
A375 ceUs;
Apoptosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(3):425-426,后插四
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the apoptotic induction of Aspisol on melanoma A375 cells.Methods The growth inhibition effect of Aspisol on A375 cells was evaluated by MTY assay.Morphological assay was observed by inverted microscope.Early apoptofic rate in A375 cells Was anyzed by flow cytometry.Results The results of MTT assay demonstrated that the growth of A375 cells was inhibited by Aspisol in a time-and concentration-dependence (P＜0.01).FCM analysis showed that Aspisol could markedly induce apeptosis;the early apoptotie rate of A375 cells exposed to different concentrations of Aspisol for 24 h were significant differences(P＜0.05)compared with control group.Conclusion Aspisol could inhibit proliferation and induce apoptosis of A375 cells.
