New Progress in Function and Structure of The Class Ⅰ Polypeptide Release Factors
- VernacularTitle:第一类肽链释放因子结构与功能研究的新进展
- Author:
Jie CHEN
;
Baofeng CHAI
;
Aihua LIANG
- Publication Type:Journal Article
- Keywords:
classⅠ release factors,cryoelectron microscopy,crystallography,NMR,molecular dynamic
- From:
Progress in Biochemistry and Biophysics
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
The process of protein synthesis is terminated by one of the three stop codons which are recognized by classⅠ polypeptide release factors.Subsequently, it could promote the hydrolysis of the ester bond of peptidy-tRNA, resulting in release of the nascent polypeptide.Recent results from cryoelectron microscopy, crystallography, NMR, molecular dynamic and biochemical experiments have shed considerable light on the function and structure of the classⅠ release factors.The progress in these aspects were summarized.
