Differentiation of Hematopoietic Stem/Progenitor Cells From Embryonic Stem Cells
- VernacularTitle:胚胎干细胞向造血干/祖细胞定向诱导分化的研究进展
- Author:
Chao YANG
;
Jiafei XI
;
Wen YUE
;
Xuetao PEI
- Publication Type:Journal Article
- Keywords:
embryonic stem cells, hematopoietic stem/progenitor cells, differentiation, in vitro
- From:
Progress in Biochemistry and Biophysics
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Embryonic stem cells(ESCs) are pluripotent cells derived from the inner cell mass of blastocyst-stage embryos, possessing permanent self-renewal and indefinite proliferative capacity in vitro. And ESCs could differentiate into the hematopoietic cell fate. Therefore ESCs may provide an alternative for hematopoietic stem cell transplantation and blood cells transfusion. Furthermore, ESCs differentiation could also provide a powerful model system to better understand the hematopoietic development and the mechanism involved. The current status for efforts to differentiate ESCs into hematopoietic lineages were reviewed.
