The changes and significance of FOX01 mRNA level in peripheral blood mononuclear cells from type 2 diabetes mellitus patients
- VernacularTitle:2型糖尿病患者FOX01 mRNA表达水平的变化及其意义
- Author:
Huifen CAI
;
Jinfang SHI
;
Guohao GU
;
Chunxiang YANG
- Publication Type:Journal Article
- Keywords:
FOX01 mRNA;
Type 2 diabetes mellitus;
real-time PCR
- From:
Chinese Journal of Clinical Laboratory Science
1985;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the forkhead box transcription factor-1(FOX01) mRNA level in peripheral blood mononuclear cells(PBMC) from type 2 diabetes mellitus(T2DM) patients and to explore the role of FOX01 in pathogenesis of T2DM.Methods PBMC was isolated from 62 T2DM patients and 40 healthy persons.FOX01 mRNA level in PBMC was measured with reverse transcription PCR and real-time fluorescent quantitative PCR.Results FOX01 mRNA level in PBMC from T2DM patients was significantly higher than that from healthy persons(P
