Detection of Metallo-?-lactamases Produced by Multi-drug Resistant Acinetobacter baumannii
- VernacularTitle:ICU多药耐药鲍氏不动杆菌金属?-内酰胺酶检测
- Author:
Yishan HUANG
;
Guangyu SUN
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Drug resistance;
Metallo-?-lactamases
- From:
Chinese Journal of Nosocomiology
2009;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate antimicrobial resistance of Acinetobacter baumannii and detect metallo-?-lactamases (MBLs) in clinical isolates from ICU. METHODS Forty-two strains of A. baumannii were isolated from sputum samples between Jul 2005 and Mar 2007 in Affiliated Hospital of North Sichuan Medical College. Bacteria identification and antimicrobial susceptibility test were performed by VITEK-32 system and K-B disk method. Meanwhile,MBLs were detected by Etest. RESULTS Cefoperazone/sulbactam with low resistance accounted for 2.4%. The resistance to imipenem was 66.7%. The resistance to other antibiotics ranged from 69.4% to 100%. Nine MBLs-producing strains were detected by Etest. CONCLUSIONS Metallo-?-lactamases produced by A. baumannii are one of important mechanisms which caused resistance to imipenem. Cefoperazone/sulbactam and polymyxin can be chosen to treat resistant A. baumannii.
