The Protective Effect of Integrin Linked Kinase on Cardiac Function in Rats with Experiment Myocardial Infarction Rat
- VernacularTitle:局部转染整合素相关激酶改善心肌梗死后大鼠的心功能
- Author:
Xin CHEN
;
Liang DING
;
Qiang ZHOU
;
Biao XU
- Publication Type:Journal Article
- Keywords:
Integrin linked kinase;
Myocardial infarction;
Cardiac function;
Vessels regeneration
- From:
Chinese Journal of Hypertension
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Background Integrin linked kinase is a new component of the cardiac mechanical stretch sensor,modulating myocardiac contractility.Objective To test the hypothesis that enhanced level of ILK expression might protect cardiac function in rats with experiment myocardial infarction.Methods Acute myocardial infarction model was established by left anterior decending coronary artery ligation and were treated with local injection of adenoviral vector expressing ILK(n=8) or placebo(n=8) around the area with myocardial infarction.ILK expression was determined by Western blot.Four weeks after surgery,myocardial function was analyzed by catheterization.Myocardial histology was analyzed by hematoxylin-eosin staining and immunohistochemistry staining.Results Local injection of ILK resulted in increases in expression of ILK reaching a peak level around 2 weeks,and decrease 4 weeks later.Compared with control rats,the rats with ILK transfection had higher +dp/dtmax[(4930.1?1074.8) mmHg/s vs(3325.2? 775.9) mmHg/s,P
