?-cell Early Insulin Secretion Function and Insulin Resistance in Various Durations and Grades in Patients with Hypertension
- VernacularTitle:中老年原发性高血压患者胰岛?细胞早期分泌与高血压病程及分级的关系
- Author:
Yaping ZHANG
;
Lixin YANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Early insulin secretion;
Insulin resistance
- From:
Chinese Journal of Hypertension
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate ?-cell early insulin secretion function and insulin resistance in different durations and grades patients with hypertension.Methods One hundred and six middle and old age(58.4?8.5) years hypertension patients were enrolled.According to hypertension durations,patients were categorized as ≤1 year group(n=35),1.1-4.9 years group(n=34),≥5 years group(n=37);while based on grades of hypertension,patients were divided as 1st grade(140-159/90-99 mmHg,n=53),2nd grade(160-179/100-109 mmHg,n=30),3rd grade(≥180/≥110 mmHg,n=23).Plasm glucose,HOMA-IR,?I30/?G30 were determined and compared among groups.Results Patients with longer duration(≥5 years) had most seriously impairment of ?-cell early secretion(?I30/?G30)[≥5 years(2.1?4.5) vs 1.1-4.9 years(10.9?4.2),vs ≤1 year(10.3?4.2),all P
