Telmisartan Reduce Serum Retinol Binding Protein 4 and Improve Insulin Resistance in Rats with Metabolic Syndrome
- VernacularTitle:替米沙坦通过降低大鼠血清视黄醇结合蛋白4改善胰岛素抵抗
- Author:
Lan CHENG
;
Lijun ZHANG
- Publication Type:Journal Article
- Keywords:
Telmisartan;
Insulin resistance;
Pioglitazone;
Serum retinol binding protein 4;
Phosphoenolpyruvate carboxykinase
- From:
Chinese Journal of Hypertension
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Background Retinol binding protein 4(RBP4) is a novel adipokine which has been related with insulin resistance.Objective To test the hypothesis that telmisartan improves glucose and lipid metabolism may be associated with inhibiting serum RBP4 and phosphoenolpyruvate carboxykinase activity in liver.Methods Thirty wistar male rats were received high fat diet to establish metabolic syndrome model and randomly to receive telmisartan [5 mg/(kg?d),n=8] or pioglitazone [20 mg/(kg?d),n=8] for 8 weeks or high-fat diet placebo(n=10).Plasma triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),fasting plasma insulin,serum RBP4,and phosphoenolpyruvate carboxykinase specific enzyme activity in liver(PEPCK) were determined.Results Telmisartan improved insulin resistance and the disorders of glucose and lipid metabolism in diet-induced insulin resistance rats [HOMA-IR,telmisartan group(3.4?1.2) vs high-fat diet group:(8.3?1.1),P
