Cytokine-induced killer cells specifically inhibits implanted gastric cancer cells
- VernacularTitle:细胞因子诱导杀伤细胞对裸鼠胃癌移植瘤的靶向抑制作用
- Author:
Chao LIU
;
Weizheng MAO
;
Baocheng ZHAO
;
Hui LI
- Publication Type:Journal Article
- Keywords:
cytokine-induced killer cell;
gastric neoplasms;
implanted tumor;
target;
cytotoxicity
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the inhibitory effect of cytokine-induced killer cells (CIK) against implanted gastric cancer cells. Methods:Gastric cancer SGC-7901 cells were subcutaneously injected into the inguina of nude mice to establish gastric cancer model. The tumor bearing mice were randomly divided into CIK group and fibroblasts group,in which mice were subcutaneously injected with fluorescence dye SP-DiI labeled CIK and fibroblasts HFL-I cells,respectively. Distribution of CIK and HFL-I cells in different tissues of gastric cancer bearing mice were observed. Meanwhile,tumor volume was measured after different treatments and tumor inhibitory rate was calculated. Tumor necrosis areas in different groups were observed. Results:SP-DiI labeled CIK was mainly located in the gastric cancer tissues 10 d after injection,and was hardly detected at the injection sites,liver,spleen and lung tissues (P
