Relationship between polymorphism of angiotensinogen gene T704C and cerebrovascular disease
- VernacularTitle:血管紧张素原基因T704C多态性与脑血管病的关系
- Author:
Jiling HE
;
Hongying SUN
;
Guoan YANG
- Publication Type:Journal Article
- Keywords:
cerebrovascular disease;
angiotensinogen;
gene,T704C;
polymorphism
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphisms of angiotensinogen(AGT) gene T704C and cerebrovascular disease(CVD).Methods AGT T704C genotype and allele were examined by PCR-RLFP in 82 patients with cerebral infarction(CI group),70 patients with intracerebral hemorrhage(ICH group) and 89 age-matched normal controls(NC group).The AGT T704C genotype and allele frequencies among the 3 groups were compared and analyzed.The effectes of AGT T704C genotype and the risk factors of stroke to induce CI snd ICH were analyzed by Logistic regression. Results The frequencies of AGT 704CC genotype and C allelic in CI group(63.4%,79.9%) were significantly higher than those in NC group(34.8%,61.2%)(allP
