Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders.
10.5535/arm.2012.36.3.340
- Author:
In Seuk JEUNG
1
;
Soyoung LEE
;
Heung Sik KIM
;
Chang Ki YEO
Author Information
1. Department of Rehabilitation Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea. sylee@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Sialorrhea;
Botulinum toxin;
Salivary gland;
Children;
Neurologic disorder
- MeSH:
Botulinum Toxins;
Botulinum Toxins, Type A;
Child;
Follow-Up Studies;
Humans;
Nervous System Diseases;
Parotid Gland;
Salivary Glands;
Sialorrhea;
Sorbitol;
Tyramine
- From:Annals of Rehabilitation Medicine
2012;36(3):340-346
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualified parent/caregiver-administered questionnaires. METHOD: A total of 17 patients (age 7.6+/-4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance. RESULTS: DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value. CONCLUSION: Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and effective method to treat sialorrhea in children with neurologic disorders.
