Mutant Prevention Concentration of Three Cephalosporins Against Staphylococcus aureus and Streptococcus pneumoniae
- VernacularTitle:头孢菌素对金黄色葡萄球菌和肺炎链球菌防耐药突变浓度研究
- Author:
Hongtao XU
;
Fengrong TAO
;
Peng ZHANG
;
Dongke CHEN
;
Tianzhi XUAN
;
Xiaoman AI
;
Yunjian HU
;
Xiuzhen ZHANG
- Publication Type:Journal Article
- Keywords:
Mutant prevention concentration;
Staphylococcus aureus;
Streptococcus pneumoniae
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To determine the mutant prevention concentration(MPC) of 3 cephalosporins against clinical isolates of Staphylococcus aureus and Streptococcus pneumoniae.METHODS Agar dilution was used to determine the minimum inhibitory concentration(MICs) and MPCs of cefaclor,cefprozil and cefuroxime against S.aureus and the MICs to Str.pneumoniae.The MPCs against Str.pneumoniae were determined by mixing-bacterium.RESULTS The MPCs and the ratio of MPC90/MIC90 of cefaclor,cefprozil and cefuroxime against S.aureus were 32,16;16,16;2,8;and the MPCs and the ratio of MPC90/MIC90 against Str.pneumoniae were 8,16;4,32;2,8,respectively.CONCLUSIONS The ability of cefuroxime for restricting the selection of resistant mutant of Str.aureus and S.pneumoniae is stronger than cefaclor and cefprozil.
