Association between polymorphism protein C inhibitor gene G10877T and male infertility
- VernacularTitle:蛋白C抑制剂基因G10877T多态性与男性不育的关系
- Author:
Peixin LU
;
Jiaying ZHANG
;
Guangheng WU
- Publication Type:Journal Article
- Keywords:
male infertility;
protein C inhibitor;
G10877 T polymorphism
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between polymorphism of protein C inhibitor(PCI)gene G10877T and male infertility,and provide theoretical basis for treatment of male infertility.Methods PCR and sequencing technique were applied to detect PCI gene G10877 T polymorphism in 53 normal control and 102 male infertility.Results There were three genotypes of wild type(G/C),hybridization mutation(G/T)and pure mutation(T/T).The analysis of sequencing indicated that in sperums of a proportion of the male infertile patients,TGG in PCI gene G10877T mutated into TGT.The contrast of BLASTB indicated that this mutation made Trp in 271 position change into Cys.Compared with control group,TT genotypic frequency and T allelic frequency in male infertility group had significant differences(P
