Effects of nerve growth factor on metabolism and function of neuroglial cells of mice
- VernacularTitle:神经生长因子对小鼠神经胶质细胞代谢及功能的影响
- Author:
Yiwei WANG
;
Ju ZHANG
;
Yongan CAO
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
nerve growth factor;
neuroglial cells;
superoxide dismutase;
malonic dialdehyde;
nonobese diabetic mice
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of nerve growth factor(NGF) on metabolism and function of neuroglial cells in the normal mice and the nonobese diabetic(NOD) mice.Methods The mice were divided into normol group and NOD group(n=10).The neuroglial cells abstracted from the normal mice and the NOD mice were randomly divided into control (with RPMI-1640) and 4 experimental groups(n=10);5,10 and 20 ?g? L1NGF and 20 ?g?L1LPS +10 ?g?L-1NGF were used in experimental groups.The activity of superoxide dismutase(SOD) and malonic dialdehyde(MDA) content in the culture solution were detected with xanthine oxidase and TBA methods.Results Compared with control group of normal mice,the activity of SOD and MDA content in neuroglial cells of the NOD mice were significantly decreased(P
