Effect of polyene phosphatidyl on synaptic plasticity in region of hippocampus CA3 of young rats
- VernacularTitle:多烯磷脂对青年鼠海马CA3区神经元突触可塑性的影响
- Author:
Sixun AN
;
Xiaoli CHEN
;
Xin HE
;
Zhiheng DONG
- Publication Type:Journal Article
- Keywords:
polyene phosphatidyl;
hippocamal CA3;
synapse;
synaptophysia;
synaptic plasticity
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the structure changes of the synapse of the neurons in hippocampus CA3 of young rats and study the basis for the mechanism of polyene phosphatidyl in providing learning and memory and the effect on synaptic plasticity.Methods A total of 20 Wistar rats with 5 months were randomly divided into polyene phosphatidyl group and normal control group.Each group had 10 rats.After 4 weeks feeding,Water maze training was peformed in all the rats for 1 weeks.The immue expressions of synapsin(SYN) of the rats in polyene phosphatidyl group and control groups were observed with immunohistochemical method and analyzed by MOTAC imagine analyzing system.The change of synapse of hippocamal CA3 was observed with electron microscope.And the other 24 to 26 months rats were selected as aged group,and fed in the same condition.Moreover,the ultrastructures of hippocamal CA3 of aged rats were observed by transmission electron microscopy(TEM).Results The SYN in polyene phosphatidyl group(0.430 0?0.022 4) was higher than that in control group(0.3567?0.0209) (P
