Effects of estrogen on behavior and norepinephrine content in habenular nucleus of depressive rats
- VernacularTitle:雌激素对抑郁症大鼠行为学及缰核内去甲肾上腺素含量的影响
- Author:
Min HUANG
;
Wei XIA
;
Hua ZHAO
- Publication Type:Journal Article
- Keywords:
depression;
estradiol;
habenular nucleus;
norepinephrine
- From:
Journal of Jilin University(Medicine Edition)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of estrogen on the behavior and the norepinephrine level in the habenular nucleus of depressive rats,and explore the mechanism of estrogen involved in the process of antidepression.Methods Thirty rats were chosen from forty male Wistar rats,which had the similar scores in open field test.The depression models of rats were established by chronic mild stress.Open field test and forced swimming test were performed to detect the behavioral changes between rats with ovary excision(OVX) and with estradiol-treated ovary excision(OV/ER).High performance liquid chromatography(HPLC) was used to observe the changes of norepinephrine level in habenular nucleus.Results After 21-day chronic mild stress,the open field test showed that the vertical motion and cross motion in OV/ER group were increased(P
