Percutaneous Microwave Coagulation Therapy Combined with ~(125)I Seeds Implantation for Advanced Lung Cancer
- VernacularTitle:经皮微波热凝固联合~(125)I放射性粒子植入治疗晚期肺癌
- Author:
Mingyao KE
;
Lingling CHEN
;
Xuemei WU
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Percutaneous microwave coagulation;
Iodine radio-isotopes;
Brachytherapy
- From:
Chinese Journal of Minimally Invasive Surgery
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and feasibility of percutaneous microwave coagulation therapy(PMCT) combined with 125I seeds implantation for the treatment of advanced lung cancer.Methods CT-guided PMCT and implantation of 125I seeds were applied to 22 cases of NSCLC,including 15 cases of squamous carcinoma and 7 cases of adenocarcinoma.The maximum diameter of the lesions ranged from 5-12 cm.The part of focuses situated at thoracic wall or surrounding the large vessels and airways was treated with 125I seed implantation,and the other parts were treated with PMCT. Results In all the patients,PMCT was done in one session with multipoint ablation,and an average of 32.4 particles of 125I seeds were implanted for each of the focuses(712 particles in total).The main postoperative complications included slight hemoptysis(7 cases),pneumothorax(4 cases),fever(17) and lung inflammation(11) after PMCT,chest fluid(6),and dislocation of the particles(2).15 cases achieved PR,5 cases were SD,and 2 cases were PD in 2 months after the operation shown by CT.The effective rate(CR + PR) was 68.2%(15/22).The chest pain was relieved in 15 patients,and improved in 4.22 of the cases were followed up for 4 to 18 months(mean 7 months).No enlargement of the chest lesion was detected during the period. Conclusions For the advanced NSCLC sized ≥ 5 cm in diameter,PMCT combined with 125I seeds implantation is safe,minimally invasive,and effective.
