Pharmacokinetic study of iguratimod in rats
- VernacularTitle:艾拉莫德在大鼠体内的药动学研究
- Author:
Feng XIAO
;
Zhaoyi YANG
;
Shangxue YAN
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
Iguratimod;
Pharmacokinetics;
Arthritis,experimental;
Mus
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(6):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the pharmacokinetics of iguratimod in rats. MethodsThe concentration ofiguratirnod in the samples was determined by HPLC method. The pharmacokineties parameters were calculated withDAS softwrare. ResultsThe mainpharmacokineties parameters of normal group(6mg/kg) were as follows:t1/2Ke:3.56h, tpeak: 4.00h, Cmax : 8.87μg/ml, AUC0.24 : 74.76μg· ml-1·h-1. The main pharmacokineties parameters of threemodel groups(3,6,12mg/kg) were as follows: t1/2Ke: 4.54,3.20,3.17h, tpcak:3.83,3.83,4.67h,Cmax:3.84, 8.31,12.69μg/ml, AUC0.24 :40.21,76. 72,117.06μg·ml-1·h-1. Except Cmax and AUC, no significant differenceswere found between the three model groups. And the differences between normal group and model group were notsignificant. ConclusionThe pharmacokinetics of rats ks fit to one-compartment model.
