Zinc suppresses airway inflammation in asthmatic rats through regulation of Th1/Th2 balance and activity
- VernacularTitle:锌通过调节Th1/Th2平衡及抗氧化降低哮喘大鼠气道炎症
- Author:
Hongyan LU
;
Xuqin MAO
;
Yu WEN
;
Ling ZHANG
- Publication Type:Journal Article
- Keywords:
zinc;
asthma;
airway inflammation;
Th1/Th2 balance;
antioxidant
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and mechanism of zinc on airway inflammation in asthmatic rats.Methods Animal model of asthma was established by OVA challenging,zinc-deficient and zinc-supplementary diet were given accordingly.Thirty-two SD rats were divided into four groups according to weight: zinc-deficient diet with OVA challenge group(group A),zinc-supplementary diet with OVA challenge group(group B),zinc-normal diet with OVA challenge group(group C) and zinc-normal diet with saline challenge group(group D).Twenty-four hours later asthma was induced,right side lungs were harvested for HE staining to observe histomorphological changes and the respective numbers of eosinophirs,neutrophils and macrophage in the bronchial mucus were counted.The contents of interferon-?(IFN-?),interleukin-4(IL-4),superoxide dismutase(SOD),malondialdehyde(MDA) and glutathione peroxidase(GPX) in lung homogenate were detected.Results Compared with group C,the number of eosinophils,neutrophils and macrophage,and the contents of SOD increased in group A,but significantly decreased in group B(P
