Clinical evaluation of testing serum ?_2-GPI/ox-LDL complexes in patients with systemic lupus erythematosus
- VernacularTitle:检测血清?_2-GPI/ox-LDL复合物对系统性红斑狼疮的临床诊断价值
- Author:
Chunni ZHANG
;
Beilei SHI
;
Xiangdong WANG
;
Junjun WANG
;
Xiaozhuan LIU
;
Ke LI
- Publication Type:Journal Article
- Keywords:
Low density lipoprotein;
Oxidative modification;
?2-glycoprotein I;
Systemic lupus erythematosus;
Atherosclerosis
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Oxidative modification of low density lipoprotein(LDL) plays an important role in the development of premature atherosclerosis in autoimmune disorders.Oxidized LDL(ox-LDL) reportedly forms stable complexes with ?2-glycoprotein I(?2-GPI),a major autoantigen for anticardiolipin antibodies,in circulation and the intima of atherosclerotic lesions. This study aims to investigate the serum ?2-GPI/ox-LDL concentration in Chinese patients with systemic lupus erythematosus(SLE),and clinical diagnostic value.Methods: The concentrations of ?2-GPI/ox-LDL complexes were analyzed in 47 SLE patients and 42 healthy controls by ELISA.Results: The serum ?2-GPI/ox-LDL concentrations were significantly higher in the SLE patients than in the controls(\U/ml vs\U/ml,P
