The structure and function and clinical implication of visfatin
- VernacularTitle:内脏脂肪素的结构、功能及临床意义
- Author:
Ying FU
;
Lihong WANG
;
Qiang LI
- Publication Type:Journal Article
- Keywords:
Visfatin;
Pre-B cell colong-enhancing factor;
Obesity;
Diabetes
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Visfatin is a recently discovered adipokine secreted by visceral adipose tissue,corresponds to pre-B cell colony-enhancing factor(PBEF), which is composed of 473 amino acid coding a 52kDa polypeptide and expressed in bone marrow,liver,muscle and so on.Visfatin binds and activates the insulin receptor,exerting insulin-mimetic effects;promotes adipose tissue to differentiate,synthesis and accumulate,which is correlated with obesity;promote vascular smooth muscle cell to mature,participating in the processes of inflammatory response and cell differentiation and apoptosis.The multi-function of visfatin increases new contents of correlated disease pathogenesis and new targets of disease management.
