Characterization of event-related potential of visual-spatial working memory in patients with ischemic white matter lesions
- VernacularTitle:缺血性脑白质损害患者视觉空间工作记忆的事件相关电位特征
- Author:
Wei JIANG
;
Jian ZHENG
;
Shifu ZHAO
- Publication Type:Journal Article
- Keywords:
White matter lesion;
Event-related potential;
Working memory
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Executive dysfunction is a typical characteristic of vascular cognitive impairment(VCI),with subcortical ischemia as its pathological basis.The aim of this study was to investigate the characteristics of event-related potential of visual-spatial working memory based on ischemic white matter lesions,and offer more electrophysiological evidence for the evaluation of VCI.Methods: We included in this study 24 patients with ischemic white matter lesions(13 mild and 11 severe cases) and 12 elderly healthy controls,and induced event-related potentials(ERP) of visual-spatial working memory from the delayed matching-to-sample task in all the participants.Results: Three waves were identified: N330,P420 and late negative component. On the two-ball-load,the N330 amplitude in the middle frontal,right frontal and occipital lobe was significantly smaller in the mild and severe lesion groups(P
