Association of Ala22/72Ser polymorphism in the catechol-O-methyltransferase gene with schizophrenia and preliminary functional exploration
- VernacularTitle:儿茶酚胺氧位甲基转移酶基因Ala22/72Ser多态性与精神分裂症的相关性及初步功能学探索
- Author:
Yan WANG
;
Yue FANG
;
Qi XU
;
Yan SHEN
- Publication Type:Journal Article
- Keywords:
catechol-O-methyltransferase(COMT);
schizophrenia(SCZ);
single nucleotide polymorphism(SNP)
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Define the association of the catechol-O-methyltransferase(COMT) gene single nucleotide polymorphism(SNP) Ala22/72Ser with schizophrenia(SCZ) in Northern Han population.Methods In 506 SCZ patients,the genotype of Ala22/72Ser of COMT gene was sequenced and typing by polymerase chain reaction(PCR)-sequencing;the severity of psychiatric symptoms of SCZ patients was scaled by positive and negative syndrome scale(PANSS);the expression of COMT gene was determined by Real-Time PCR.Results In SCZ patients,the overall score of positive scale and general psychopathology scale were significantly increased in Ser and Ser/Ala carriers(P
