The effect of Cyclosporin A on sevoflurane postconditioning in focal cerebral ischemia
- VernacularTitle:环孢素对七氟醚后处理诱导脑保护作用的影响
- Author:
Ming XIA
;
Weiyan LI
;
Hailong DONG
;
Lize XIONG
- Publication Type:Journal Article
- Keywords:
Sevoflurane;
Ischemic/reperfusion injury;
Postconditioning;
Brain;
Cyclosporin A;
Mitochondrial permeability transition pore
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Ischemic cerebral injury is a common complication during perioperative period.We found that ischemic postconditioning and various non-ischemic postconditioning(e.g.inhalation anesthetics) could significantly attenuate ischemic cerebral injury.The present study was to investigate the effect of Cyclosporin A on sevoflurane postconditioning in focal cerebral ischemia.Methods:Fifty male SD rats were randomly assigned to five groups (n=10 each): control group(con),1.0MAC group(sevo),1.0MAC+ Cyclosporin A group(sevo+CsA),1.0MAC+ vehicle group(sevo+vehicle)and Cyclosporin A group(CsA).All animals were subjected to right middle cerebral artery occlusion(MCAO) for 120min followed by reperfusion for 72h.The animals in sevo groups were given 1.0MAC sevoflurane inhalation from 20min before to 10min after reperfusion.The animals in CsA groups were given CsA by ICV injection before sevoflurane postconditioning.The neurological deficit scores(NDS) were recorded at 24h,48h,and 72h after reperfusion.Infarct volume percentage was determined after the last NDS assessment.Results:The infarct volume percentage ratio of Sevo, Sevo+CsA,CsA and Sevo+vehicle groups were 0.31?0.04,0.25?0.04,0.30?0.03 and 0.33?0.05,respectively(P
