Carbapenemase of OXA-23 Prevailed in Acinetobacter baumannii Isolated from Burned Patients
- VernacularTitle:OXA-23碳青酶烯酶在鲍氏不动杆菌烧伤分离株中流行
- Author:
Yuhong PAN
;
Qinghe SU
;
Xuan HUANG
;
Huali CHENG
;
Rongfang CHEN
;
Feng ZHANG
- Publication Type:Journal Article
- Keywords:
Carbapenemase;
Acinetobacter baumannii;
?-Lactamases
- From:
Chinese Journal of Nosocomiology
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the disseminateion of the carbapenemase in Acinetobacter baumannii isolated from burned patients.METHODS Susceptibility tests of 20 strains of A.baumannii isolated from burned patients to 20 kinds of antimicrobial drugs were detected.Subsequently,seven genes encoding carbapenemase,including OXA-23,OXA-24,OXA-51,OXA-58,IMP,VIM and SIM,were detected by PCR and genes of partial positive products were sequenced.RESULTS Drug resistances to ?-lactam antibiotics of 20 strains of A.baumannii isolated from burned patients all exceeded 85% except to levofloxacin or cefoperazone/sulbactam.Nineteen strains(95%) were OXA-23 genes positive and all other genes were negative.Through sequence and Blast analysis,OXA-23 gene products were identical with that of CAB69042.1.CONCLUSIONS The multidrug resistance of A.baumannii isolated from burned patients to ?-lactam antibiotics is critical.Carbapenemase of OXA-23 prevails in A.baumannii isolated from burned patients.
