Drug Combination on in vitro Activities of Multi-drug resistant Pseudomonas aeruginosa
- VernacularTitle:联合用药对多药耐药铜绿假单胞菌的体外活性
- Author:
Liwen LIU
;
Kejun HAN
;
Zhengrong CHEN
- Publication Type:Journal Article
- Keywords:
Drug combination;
Multi-drug resistantce;
Pseudomonas aeruginosa
- From:
Chinese Journal of Nosocomiology
2004;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the in vitro inhibitory effects of antibacterials in combination carbapenem against multiresistant Pseudomonas aeruginosa.METHODS The protocol was designed by checkboard method and the MIC of the two antibiotics in combination was determined by broth dilution method.FIC was calculated according to MIC results.RESULTS The MIC50 and MIC90 of eight kinds of antibiotics were lower to 1-16 times and 1-64 times,respectively.The synergistic and additive antibacterial activity was seen in ceftazidime with amikacin,piperacillin with tobramycin and azlocillin with sulbactam.The lomefloxacine with ampicillin and lomefloxacine with ceftriaxone were not correlated.CONCLUSIONS Antibacterial activity of ceftazidime combined with amikacin against carbapenem-multiresistant P.aeruginosa is the best.
