Integron-mediated multidrug resistance in clinical multi-resistant Pseudomonas aeruginosa
- VernacularTitle:多重耐药铜绿假单胞菌中Ⅰ类整合子的研究
- Author:
Peiming LIU
;
Huilin YAO
;
Shihai LU
;
Nan ZHUANG
- Publication Type:Journal Article
- Keywords:
multidrug resistance;
Pseudomonas aeruginosa;
integron;
gene
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the action of integron-mediated multidrug resistance in clinical multi-resistant Pseudomonas aeruginosa in Huaibei area.Methods The antibiotic susceptibility of 13 different antibiotics of 36 multi-drug resistant P.aeruginosa was tested by K-B.The three-dimensional method was taken to differentiate the various beta-lactamases.The integron was determined by PCR with integron-specific primer.Results The positive rate of integron detection in multi-resistant Pseudomonas aeruginosa was 86.1%.Two kinds of integron with different length were found,i.e.1 000 bp and 2 000 bp.PSE-1,aadA2,aadB,aac(6)-II and CARB-8 were the resistance-related gene cassette in the integrons.Conclusions Integron may enroll in multiple resistance of multi-resistant Pseudomonas aeruginosa.
