Research for difference and sense of B cell epitope human hepatitis virus B genotype-B and genotype-C
- VernacularTitle:乙型肝炎病毒B基因型和C基因型B细胞表位的差异及意义
- Author:
Guoqiang WANG
;
Juxia NIU
;
Ankui JIA
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Genotype;
Epitopes,B-Lymphocyte
- From:
International Journal of Laboratory Medicine
2010;31(1):37-38,41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the difference and sense of B cell epitope of S protein HBV genotype B and genotype C. Methods Search for amino acid sequence of S protein of HBV genotype C and genotype B from GcnBank for international network and forecast B cell epitope of S protein of HBV genotype band genotype C by DNAStar Bio-software and by Kolaskear-tongaonaka method through the international network. Results There are five B cell epitopes about amino acid of S protein of HBV genotype B and three HBV genotype C and antigenic index (1. 0798) of amino acid of S protein of HBV genotype B is higher than that of HBV genotype C (1. 0729). Conclusion Human hepatitis B genotype C is easier to develop chronic hepatitis than that of Human hepatitis B genotype B, It may be related with the fact that there arc fewer B cell epitopes and lower antigenic index about S protein in hu-man hepatitis B genotype C than that in human hepatitis B genotype B.
