Antimicrobial Resistance Surveillance on Hospital-and Community-acquired Pathogens in 10 Teaching Hospitals in China
- VernacularTitle:全国10所医院院内与社区感染常见病原菌耐药性分析
- Author:
Qiwen YANG
;
Yingchun XU
;
Xiuli XIE
;
Hui WANG
;
Yunjian HU
;
Yuxing NI
;
Jingyong SUN
;
Yunsong YU
;
Haishen KONG
;
Lin HE
;
Weiyuan WU
;
Huifen YE
;
Yinmei YANG
;
Ziyong SUN
;
Xuhui ZHU
;
Mingqing TONG
;
Wangsheng ZHAO
;
Yaning MEI
;
Yong LIU
;
Zhijie ZHANG
;
Qiong DUAN
;
Dan LI
;
Minjun CHEN
- Publication Type:Journal Article
- Keywords:
Resistant surveillance;
Microbiology;
Streptococcus pneumoniae;
Escherichia coli;
Klebsiella pneumoniae;
Meticillin-susceptible Staphylococcus aureus;
SEANIR resistant surveillance
- From:
Chinese Journal of Nosocomiology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the antimicrobial resistance of hospital-and community-acquired pathogens collected from 10 teaching hospitals located at different areas in China in 2006.METHODS According to the study protocol,the strains of Streptococcus pneumoniae,meticillin-susceptible Staphylococcus aureus(MSSA),Escherichia coli and Klebsiella pneumoniae were collected and sent to the central lab for reidentification and susceptibility testing.The minimal inhibitory concentrations(MICs) of antimicrobial agents against Str.pneumoniae were determined by Etest method and MICs of antimicrobial agents against S.aureus,E.coli and K.pneumoniae strains were determined by agar dilution method.WHONET5.4 software was used to analyze the data.RESULTS Among 353 Str.pneumoniae strains,74.2% were penicillin-susceptible(PSSP),9.6% were penicillin-intermediate(PISP) and 16.2% were penicillin-resistant(PRSP).Strains from different hospitals showed different sensitivity to penicillin.Among ?-lactam antibiotics,cefuroxime showed the lowest susceptibility rate of 0%(for PRSP) to 76.7%(for PSSP).The susceptibility rate to ceftriaxone and amoxicillin-clavulanic acid was 98.1% and 98.9% in PSSP group,61.8% and 64.7% in PISP group,and 15.8% and 10.5% in PRSP group.The ESBLs rate was 56.2% among 267 Escherichia strains and 42.7% among 206 K.pneumoniae strains.For ESBLs-producing strains,the susceptibility rates to cefotaxime and ceftriaxone were low and the rate to ceftazidime was relatively high among ?-lactam antibiotics.73.4% MSSA strains produced ?-lactamase.?-Lactam antibiotics tested showed high susceptibility against MSSA strains.The susceptibility rate was 98.9-100%.The susceptibility rate to ciprofloxacin and levofloxacin was 80.8% and 88.1%,separately.CONCLUSIONS Fluoroquinolones show high susceptibility against Str.pneumoniae.Ceftriaxone and amoxicillin-clavulanic acid have relatively high susceptibility among ?-lactams.For MSSA and non-ESBLs-producing E.coli and K.pneumoniae strains,?-lactams show high susceptibility.For ESBLs-producing E.coli and K.pneumoniae strains,the susceptibility rates to cefotaxime and ceftriaxone are low and that to ceftazidime,cefepime and cefoperazone-sulbactam are relatively high.