In-vitro Activity of Sulbactam in Combination with Minocycline Against Multidrug-resistant Acinetobacter baumannii
- VernacularTitle:舒巴坦与米诺环素对多药耐药鲍氏不动杆菌体外联合药敏研究
- Author:
Jiyong YANG
;
Yanping LUO
;
Lu XIN
- Publication Type:Journal Article
- Keywords:
Sulbactam;
Minocycline;
Acinetobacter baumannii
- From:
Chinese Journal of Nosocomiology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the antibacterial effect of sulbactam combined with minocycline against 110 multidrug-resistant Acinetobacter baumannii strains.METHODS Checkerboard method was designed and agar dilution method was used for the MIC testing of sulbactam combined with minocycline against 110 multidrug-resistant A.baumannii strains,and the fractional inhibitory concentration(FIC) index was calculated according to MIC value.RESULTS The MIC50 of sulbactam was reduced significantly and the antimicrobial activities had been reinforced remarkably when combined with minocycline.The FIC results suggested that the main interaction be synergism(22%) and additivity(74%),with only 5% non-effect and without antagonism.CONCLUSIONS Synergism and additivity are the main effects for subactam when combined with minocycline against multidrug-resistant A.baumannii.
