Gap junction remodeling and stem cell transplantation following acute myocardial infarction
- VernacularTitle:急性心肌梗死缝隙连接重构与干细胞移植治疗
- Author:
Honghong KE
;
Guoqiang ZHONG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Gap junctions(GJ) form the chemical signal channels between cardiocytes.The core proteins of these channels are the connexins(Cx).The quantity or distribution of Cx will lead to the remodeling of GJ, which contributed to arrhythmia and remodeling following the acute myocardial infarction.GJ remodeling is the key reason and pathological basis of arrhythmia following acute myocardial infarction.How to increase the number of myocardial cells and lighten or reverse the heart reconstitution have become a focal point.In the acute myocardial infarction cell transplantation treatment, stem cells are characterized by self-renewal and multi-directional differentiation have been paid great attention.This study summarized the basis and clinical research of GJ structure, function, distribution, remodeling and stem cell transplantation treatment following myocardial infarction.
