In Vitro Effect of Secnidazole Benzoate on Trichomonas vaginalis
- VernacularTitle:塞克硝唑苯甲酸酯体外抗阴道毛滴虫作用的研究
- Author:
Xiaoxiang ZHANG
;
Shanshan ZHENG
;
Meimei ZHU
- Publication Type:Journal Article
- Keywords:
Secnidazole benzoate;
Trichomonas vaginalis;
Anti-trichomonas effect;
MTT colorimetric assay
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the trichomonacidal effect of secnidazole benzoate in vitro.Methods Trichomonas vaginalis was cultured in liver extract medium in 96-well microplate.The culture suspension of Trichomonas vaginalis was divided into four groups:secnidazole benzoate, secnidazole, metronidazole and control, with medium as blank control.MTT colorimetric assay was applied to determine the inhibitory effect of secnidazole benzoate on the proliferation of Trichomonas vaginalis.The culture suspension was transfered into test tubes and divided into same groups to observe inhibitory effect by the classical microscopic counting method.Results After 24 h incubation, the proliferation of the parasites was concentration-dependent by secnidazole benzoate(t=9.02, P
