Relationship between smooth muscle cell hyperplasia and plasma tissue factor after percutaneous coronary intervention in porcine model
- VernacularTitle:猪冠状动脉介入损伤后血管壁平滑肌细胞增生与血浆组织因子水平的关系
- Author:
Shaojun LI
;
Ning LI
;
Zhitao LI
- Publication Type:Journal Article
- Keywords:
PCI;
Restenosis;
Smooth muscle cell;
Tissue factor
- From:
Chinese Journal of Interventional Cardiology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between plasma levels of tissue factor(TF) in the circulation and the development of smooth muscle cells(SMC) hyperplasia after percutaneous coronary intervention(PCI) in porcine models.Methods Thirty swines were used and their coronary arteries were injured by balloon dilatation.Morphological measurements included neointimal area and the extent of area stenosis.Plasma TF level was measured before and after PCI.The relationship between TF and neointimal area was calculated.Results Different degrees of intimal hyperplasia were found among all vessels and the rate of restenosis was 60%.Plasma TF levels were significant higher in vessels which subsequently developed restenosis(30 minutes after PCI: 688.36?91.57 ng/L vs 514.87?68.73 ng/L,24 hours after PCI: 706.09?89.59 ng/L vs 539.22?70.51 ng/L,P
