Progress Toward Molecular Determinants of the Pathogenesis of Disease Due to Nontypeable Haemophilus influenzae
- VernacularTitle:不可分型流行性感冒嗜血杆菌致病机制研究进展
- Author:
Guozhong TIAN
;
Li ZHANG
;
Zhujun SHAO
- Publication Type:Journal Article
- Keywords:
Nontypeable haemophilus influenzae;
Molecular determinants;
Pathogenesis
- From:
Chinese Journal of Vaccines and Immunization
2008;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Haemophilus influenzae (Hi) is a pathogen exclusively found in humans. It causes a wide range of infections from the upper respiratory tract to serious invasive diseases. Such as pneumonia, septicemia and meningitis. Strains of Hi are usually classif ied into six serotypes a to f and nontypeable H. influenzae (NTHI) according to the antigenicities and compositions of their polysaccharide capsules. Hib was a common cause of serious infections in younger children. The polysaccharide-protein conjugate vaccines against Hib had almost eliminated H. influenzae as a cause of pediatric meningitis. However, NTHI remains an important pathogen, particularly in children and the elderly. Efforts to understand and control NTHI disease have been hampered by the diversity of these bacteria. This review introduced the study progress about pathogenic mechanism of NTHI. In order to provide the help for development of vaccine, clinic treatment and prevent the occurrence of diseases causing by NTHI.
