Aassociation between gene polymorphism of interleukin-4 C590T and serum level of interleukin-4 and atherothrombotic cerebral infarction
- VernacularTitle:白介素-4 C590T基因多态性与血清白介素-4水平及动脉粥样硬化性血栓性脑梗死的关系
- Author:
Zhenyu TANG
;
Qidong YANG
;
Lin ZHOU
- Publication Type:Journal Article
- Keywords:
atherothrombotic cerebral infarction;
interleukin-4;
gene polymorphism
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between gene polymorphism of interleukin(IL)-4 C590T and serum level of IL-4 and atherothrombotic cerebral infarction(ATCI).Methods The gene polymorphisms of IL-4 C590T in 159 patients with ATCI and 151 normal control subjects were carried out by polymerase chain reaction(PCR)-restriction fragment length polymorphism(RFLP).The serum level of IL-4 in normal control group was determined with enzyme linked immunosorbent assay(ELISA) method.Results In the normal control group,the serum level of IL-4 in TT genotype[(31.85?5.68) pg/ml] was higher significantly than those in TC[(28.67?6.00) pg/ml] and CC genotypes[(20.98?0.99) pg/ml],TC genotype was higher significantly than CC genotype(all P0.05).Conclusions IL-4 590T allele is associated with higher level of serum IL-4.The C590T polymorphism is not associated with the incidence of ATCI.
