Changes of dopaminergic neurons in substantia nigra compact of the aged rats
- VernacularTitle:老年大鼠黑质致密部多巴胺能神经元的变化
- Author:
Chenghua XIAO
;
Hui MIAO
;
Yu SUN
- Publication Type:Journal Article
- Keywords:
aging;
substantia nigra compact;
dopaminergic;
neurons;
tyrosine hydroxylase
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of dopaminergic(DA) neurons in substantia nigra compact of the aged rats.Methods Using RT-PCR,Western blot,immunohistochemistry and electron microscope to detect the levels of TH mRNA and TH protein,the number and the ultrastructure of TH-positive neurons in the substantia nigra compact of the aged rats(≥24 months),and comparing those with adult rats(4～5 months).Results The level of TH mRNA(0.66?0.12) in substantia nigra compact of the aged rats was much lower than that in the adult rats(1.09?0.08)(P0.05).However,the number of TH-positive neurons in the caudal of substantia nigra compact of the aged rats was much lower than that of the adult rats(P
