Study of the damage effects of Helicobacter pylori on dopaminergie cell line SH-SY5Y in vitro
- VernacularTitle:幽门螺杆菌对多巴胺能细胞系SH-SY5Y损伤作用的体外研究
- Author:
Renkai LIU
;
Li FENG
;
Bo XIAO
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Helicobacter pylori;
oxidative stress;
mitochondria dysfunction
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the damage effects and its mechanism of Helicobacter pylori(HP) on dopaminergie cell line SH-SY5Y in vitro.Methods The cellular survival rate,the level of cellular activated oxygen and the activity of mitochondrion respiratory chain complexes were measured in dopaminergic cell line SH-SY5Y after adding secretory components of HP(HP group),MPP+(PD group) and culture solution(control group).Results The cellular survival rates in the HP group and PD group were decreased,the cellular survival rate of high concentration HP subgroup was dramatically decreased than those in the middle and low concentration subgroups(all P
