Effects of electric stimulation treatment on motor function and expression of microtubule-associated protein-2 and survivin of brain tissue in cerebral infarction rats
- VernacularTitle:电刺激治疗对脑梗死大鼠运动功能和脑组织微管相关蛋白-2及存活素表达的影响
- Author:
Zhihua SI
;
Xiuqing ZHANG
;
Jiyou TANG
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
electric stimulation treatment;
microtubule-associated protein-2;
survivin
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of electric stimulation on motor function and expression of microtubule-associated protein-2(MAP-2) and survivin of brain tissue in the cerebral infarction rats.Methods Cerebral infarction rat models were made using middle cerebral artery occlusion.After cerebral infarction for 24 h,the rats were respectively treated with electric stimulation on paralyzed(unilateral)or bilateral limbs for 3 d,7 d,14 d,21 d.By using beam walking test(BWT) and immunehistochemistry,the motor function and the expression of MAP-2 and survivin of brain tissue in the border of cerebral infarction area were examined at various time following treatment.Results Compared to control group,the electric stimulation groups showed significant increase in BWT scores after treatment 7 d(all P0.05).In the electric stimulation groups,the expression of survivin of brain tissue were obviously higher than those in the sham operation group at various time points(all P0.05).Conclusions Treatment with electric stimulation,in particular bilateral electric stimulation,can promote the recovery of motor function of paralyzed limbs and induce up-regulation of expression of MAP-2 and survivin in the brain tissue of cerebral infarction rats.
