Investigate on the polymorphism of brain-derived neurotrophic factor gene C270T in patients with sporadic Alzheimer's disease
- VernacularTitle:散发性Alzheimer病患者脑源性神经营养因子基因C270T多态性的研究
- Author:
Guangsheng GAO
;
Shuwen XU
;
Dongfeng LI
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
brain-derived neurotrophic factor;
gene polymorphism
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the polymorphisms of brain-derived neurotrophic factor(BDNF) gene C270T and sporadic Alzheimer's disease(SAD) in Han Chinese.Methods The polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP) was used to detect BDNF gene C270T genotype and allele frequencies in 55 SAD patients and 80 age-and sex-matched healthy people(as normal control group).Results The frequencies distribution of BDNF gene C270T genotype and allele in the normal control group were suit to Hardy-Weinberg equilibrium(?2=0.167,P=0.682).The frequencies distribution of genotype and allele in the SAD group[C/C:52(94.5%),C/T:3(5.5%) and C:97.27%,T:2.73%]and normal control group[C/C:74(92.5%),C/T:6(7.5%) and C:96.25%,T:3.75%] were no statistical differences.Conclusion There is no association between the polymorphisms of BDNF gene C270T and SAD in Han Chinese.
