Oxacillin Resistance in 175 Clinical Staphylococcus aureus Strains
- VernacularTitle:耐苯唑西林金黄色葡萄球菌的测定及耐药性分析
- Author:
Minghai HUANG
;
Qunying CHEN
- Publication Type:Journal Article
- Keywords:
Oxacillin-resistant Staphylococcus aureus;
?-Lactamases;
Drug resistance
- From:
Chinese Journal of Nosocomiology
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the incidence of ?-lactamases and oxacillin-resistant Staphylococcus aureus and their drug resistance in our hospital. METHODS The clinical isolates were identified by VITEK-60 of Bio-Merieux of France. K-B agar diffusion method and confirmed test were used to detect the drug resistance of oxacillin-resistant S. aureus. RESULTS Among 175 S. aureus isolates, the incidence of ?-lactamases was 94.3% and the incidence of oxacillin-resistant S. aureus was 28.6%. Oxacillin-resistant S. aureus was mostly isolated from pus/wound (52.0%), then from sputum and throat swab (32.0%). CONCLUSIONS To cure infections caused by ?-lactamases-noproducing S. aureus, penicillin is the best choice. For infections caused by ?-lactamases-producing but oxacillin sensitive S. aureus, the first generation cephalosporins are the best choice, while curing infections caused by ?-lactamases-producing and oxacillin- resistanct, S. aureus nitrofurantoin and linezolid are the best choice. The resistance rate to vancomycin is zero. It should be carefully used in therapy.
